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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
29.39
Human Site:
Y28
Identified Species:
43.11
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
Y28
L
R
G
E
A
I
K
Y
L
T
E
A
L
Q
S
Chimpanzee
Pan troglodytes
XP_509931
527
59578
Y28
L
R
G
E
A
I
K
Y
L
T
E
A
L
Q
S
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
W28
L
R
G
G
R
A
W
W
F
T
P
V
I
P
P
Dog
Lupus familis
XP_851216
527
59504
Y28
L
R
G
E
A
I
K
Y
L
T
E
A
L
E
S
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
Y28
L
R
S
E
A
T
K
Y
L
T
E
A
L
Q
S
Rat
Rattus norvegicus
XP_216727
527
59187
Y28
L
R
S
E
A
T
K
Y
L
T
E
A
L
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
Y36
R
K
N
E
A
T
T
Y
L
T
G
A
L
Q
S
Chicken
Gallus gallus
Q5ZKQ6
527
59609
Y28
L
R
A
E
A
V
K
Y
L
T
E
T
L
E
S
Frog
Xenopus laevis
NP_001083783
527
59670
Y28
L
R
A
E
A
S
K
Y
L
S
E
V
L
S
S
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
F28
L
R
P
E
S
S
R
F
L
L
Q
V
L
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
Y30
I
R
S
E
N
S
S
Y
L
A
E
Q
L
L
P
Honey Bee
Apis mellifera
XP_001120791
454
52119
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
F37
V
K
L
C
V
K
L
F
L
D
H
D
K
E
T
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
P28
R
S
A
I
E
R
E
P
V
S
S
A
L
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
E30
L
K
V
D
A
L
E
E
A
A
A
F
L
D
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
F78
K
Q
Q
E
R
G
L
F
I
D
Q
S
G
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
26.6
93.3
N.A.
86.6
86.6
N.A.
60
73.3
66.6
40
N.A.
40
0
6.6
13.3
P-Site Similarity:
100
100
40
100
N.A.
86.6
86.6
N.A.
66.6
86.6
73.3
73.3
N.A.
46.6
0
40
33.3
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
20
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
0
57
7
0
0
7
13
7
44
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
13
0
7
0
7
7
% D
% Glu:
0
0
0
69
7
0
13
7
0
0
50
0
0
25
0
% E
% Phe:
0
0
0
0
0
0
0
19
7
0
0
7
0
0
0
% F
% Gly:
0
0
25
7
0
7
0
0
0
0
7
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
7
0
0
7
0
19
0
0
7
0
0
0
7
0
0
% I
% Lys:
7
19
0
0
0
7
44
0
0
0
0
0
7
0
7
% K
% Leu:
63
0
7
0
0
7
13
0
69
7
0
0
75
13
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
7
0
0
7
0
0
7
13
% P
% Gln:
0
7
7
0
0
0
0
0
0
0
13
7
0
32
0
% Q
% Arg:
13
63
0
0
13
7
7
0
0
0
0
0
0
0
7
% R
% Ser:
0
7
19
0
7
19
7
0
0
13
7
7
0
7
57
% S
% Thr:
0
0
0
0
0
19
7
0
0
50
0
7
0
0
7
% T
% Val:
7
0
7
0
7
7
0
0
7
0
0
19
0
7
0
% V
% Trp:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
57
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _